Modern Biomolecular Crystallography II

Location: 
California State University - Fullerton
City, State: 
Fullerton, CA
Instructor(s): 
Katherine Kantardjieff (CSU Fullerton), Blake Gillespie (CSU Channel Islands), Eric Hnath, (RIgaku MSC), Bernhard Rupp (Livermore, CA), Clyde Smith (Stanford Synchrotron Radiation Laboratory)

 

Practically all information about the molecular structure of matter at atomic resolution is the result of crystallographic analysis. Substantial advancements in crystallographic techniques made over the last 25 years allow individuals with quite diverse background and preparation, and sometimes little training, to use crystallography as a tool to address a specific hypothesis-driven structural problem. Ironically, as a result of methodological advances, crystallography as a science has been misunderstood in recent years, sometimes thought of as too easy or irrelevant beyond the solid state. Crystallography continues to make major contributions to the pharmaceutical industry as part of the process of rational drug design, to the field of synthetic chemistry by facilitating synthetic processes, to materials science in relating structure to function, and to medicine by identifying on the molecular level, structural features that play key roles in disease processes. Structural proteomics is a key underpinning of pharmaceutics and biotechnology in the 21st century. The need for skilled crystallographers had never been greater, and teaching crystallography in a way that attracts the most talented young people is a must, if the science of crystallography is to remain vibrant.

Modern Biomolecular Crystallography II is a five-day workshop that familiarizes faculty with the process of macromolecular structure determination by single crystal x-ray diffraction. MBCII discusses theory and methods, and it provides participants hand-on experience in protein production and crystallization, structure solution and refinement, interpretation and validation of protein crystal structures, as well as aspects of structural bioinformatics such as targeting, in silico modeling and mutagenesis, and structure-guided drug design. Remote access to instrumentation is also demonstrated. Participants will gain an understanding of crystallography terminology commonly used in publications, and they will learn what is required to successfully undertake, complete and publish a structure determination. Experiments developed for the undergraduate curriculum will be described and disseminated.

We have gathered a fabulous team of facilitators for our workshop:

  • Katherine Kantardjieff, Director, W.M. Keck Foundation Center for Molecular Structure at CSU Fullerton Blake Gillespie,
  • Professor, Department of Chemistry and Biochemistry, CSU Channel Islands Eric Hnath, RIgaku MSC Bernhard Rupp, CEO, q.e.d. life science discoveries, Livermore, CA
  • Clyde Smith, Staff Scientist, Stanford Synchrotron Radiation Laboratory

You may follow the links above to the facilitator biographical sketches, and click here for the tentative MBCII schedule, as well as all future workshop materials, presentation videos, and post-workshop evaluation forms. Presentations will be webcast by iLinc? Communications. Chemists, biochemists and biologists have all been encouraged to apply. Space is limited, and although we would truly like to accommodate everyone, we have selected participants based on their background and the quality of their personal statement. Participants have provided a thoughtful narrative on why they wish to attend, what they hope to learn, and how this will help them with their research and/or teaching endeavors at their home institution. We're sorry, but online registration is now closed.

If you wish to attend the webcasts, please contact Katherine Kantardjieff kkantardjieff@fullerton.edu.